This is followed by nuclear-GR deacetylation by histone deacetylase 2, a required event for NF-B transcriptional repression (42, 43)
[1] [3] The 5-year survival for IPF ranges between 20 and 40%, [81] a mortality rate higher than that of a number of malignancies, including colon cancer, multiple myeloma and bladder cancer
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However, the poor fidelity to the in vivo conditions limits its efficacy, widening the translational gap between preclinical studies and clinical trials ( Hydrogel-based cell culture systems, spheroids and organoids, or their combination currently represent valid 3D cell culture models ( e.g
